Anyone use content distribution networks?

I'm faced with handling some very large peak traffic on a
site and I'm
looking into using some CDNs such as Akamai to provide the
extra
bandwidth and responsiveness. I haven't found a lot online
about dealing
with the convergence of caching and ssl/aspx pages. My aspx
pages nearly
all have some sort of personalization and dynamic content on
them. Can
someone point me in the right direction? I have some ideas,
but would
love to hear from someone who's been here before.

Thanks,

Brian

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