.
Ocular manifestations of toxic epidermal necrolysis
associated with allopurinol use
T. O. Bennett, J. Sugar and S. Sahgal
http://archopht.ama-assn.org/cgi/content/abstract/95/
8/1362
A 54-year-old man was receiving allopurinol therapy to treat
hyperuricemia that followed an inferior wall, myocardial
infarction. After three weeks of allopurinol therapy, the
patient developed signs and symptoms of toxic epidermal
necrolysis that included pseudomembranous conjunctivitis
with ulcerative lesions on the lids and conjunctiva, and
punctate corneal staining with subsequent corneal abrasions.
Treatment with topical antibiotics and artificial tears
relieved the symptoms somewhat, but punctate staining and
dry eyes persisted after 14 months of follow-up. Bilateral
corneal ulcers developed and necessitated conjunctival flaps
in each eye. Visual acuity in each eye was 20/40.
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