You might wonder if EGF induces angiogenesis since it is a
growth
factor. It does not. Here are some details from post# 80907
before I
tried it:
....I asked her how she knew EGF did not cause angiogenesis.
My skin
is doing well, so now I'd like to thicken it...so how do I
know EGF
won't cause a problem? (FYI - She is not trying to sell it
to me, she
uses it and knows of it as a skin care consultant) She
answered:
"I'd read about it before, and shared anecdotal
experiences with
others who have used EGF -- doing a google search, most
research
focuses on wound healing and cancer -- but the initial
results are
interesting -- EGF plays a role in regulating angiogenesis
as far as
on the skin --
http://72.14.203.104/search?q=cache:Sy5mLB9_o
_QJ:www.emedicine.com/
plastic/topic457.htm+EGF+angiogenesis+skin&hl=en&gl=
us&ct=clnk&cd=2
http://72.14.203.104/search?q=cache:hLpdiA
ZnG6oJ:www.findarticles.com/
p/articles/mi_qa3977/is_200405/ai_n9420609/
pg_2+EGF+angiogenesis+skin&hl=en&gl=us&ct=clnk&a
mp;cd=4
'"Some of these factors act directly on the cells,
such as VEGF, FGF
and thymosin b4, whereas others, such as PGE2, EGF, TGFb and
TNFa,
regulate the inflammatory phase of wound healing and may not
directly
affect angiogenesis."'
'"EGF has been used in many wound model systems with
considerable
success in animals. Increased formation of healing tissue
induced by
EGF has been observed in the perforated mesentary of rats
but it is
not likely that the mechanism involved angiogenesis
directly."'
from http://72.14.203.104/search?q=cache:RVV0T9pPF04
J:www.eurekah.com/
chapter.php%3Fchapid%3D45%26bookid%3D6%26catid%3D3+EGF+ang
iogenesis+skin&hl=en&gl=us&ct=clnk&cd=9
There are more links, but from what I gather, EGF plays an
important
role in wound healing. Part of wound healing involves
angiogenesis,
providing new blood flow to the tissues. EGF does not
provide this
function; fibroblast growth factor (FGF) is probably most
responsible
for providing angiogenesis."
Have a wonderful day!
-Artist
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