Strategies for testing where multiple php.ini settings are necessary

Hey guys;

Does anyone have any strategies that they've employed for
running  
tests where multiple php.ini settings need to be tested? 
I've got a  
caching mechanism that auto-discovers available external
caching  
mechanisms and uses them in a particular order.  If an
extension is  
loaded on top of another mechanism that is further down in
the stack,  
I can't test that the further one is properly loaded.

Any thoughts would be appreciated.
-T

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