Tramadol <http://www.drugstoretm.com/products/buy/tramadol>; is a
medication indicated for the management of moderate to moderately severe
pain.
Tramadol <http://www.drugstoretm.com/products/buy/tramadol>; received
U.S. Food and Drug Administration (FDA) approval in March 1995. Tramadol
has been prescribed in more than 55 million patients worldwide and
ULTRAM has been prescribed in more than 21 million patients in the
United States.
Tramadol <http://www.drugstoretm.com/products/buy/tramadol>; is a
centrally acting synthetic analgesic, not a non-steroidal
anti-inflammatory drug (NSAULTRAMID). Tramadol
<http://www.drugstoretm.com/products/buy/tramadol>; has no
anti-inflammatory activity and no potential for
prostaglandin-mediated side effects. Unlike NSAIDs, Tramadol
<http://www.drugstoretm.com/products/buy/tramadol>; does not have the
potential to compromise the efficacy of certain antihypertensive
agents (diuretics, beta blockers, ACE-inhibitors).
While the mode of action of Tramadol
<http://www.drugstoretm.com/products/buy/tramadol>; is not completely
understood, animal studies suggest that at least two complementary
mechanisms appear applicable: binding of parent and M1 metabolite to
opioid receptors and weak inhibition of the reuptake of norephinephrine
and serotonin.
For the treatment of painful conditions, Tramadol
<http://www.drugstoretm.com/products/buy/tramadol>; 50 mg can be
administered as needed for relief every four to six hours, not to
exceed 400 mg per day. For elderly patients over 75 years of age,
the maximum dose should not exceed 300 mg per day. In patients with
preexisting kidney problems (creatinine clearance of less than 30
mL/min) or with advanced cirrhosis of the liver, see Dosage and
Administration in the full U.S. Prescribing Information. For some
patients, starting Tramadol
<http://www.drugstoretm.com/products/buy/tramadol>; at a lower dose and
titrating slowly upward improves tolerability.
The most frequently reported side effects experienced with Tramadol
<http://www.drugstoretm.com/products/buy/tramadol>; were constipation,
nausea, dizziness, headache, somnolence, and vomiting.
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